The human gastrointestinal tract has a diverse population of microorganisms, especially bacteria, fungi, and viruses. These are collectively referred to as the microbiota. Some of these colonies are passed on from mother to child during birth through the vaginal canal. However, babies who are born by cesarean section miss out on this microbiota transfer, and that puts their long-term health at risk since they will be more susceptible to immune-related complications later in life. Now a team of researchers has discovered that a mother’s microbiota can be transferred to an infant after birth through a procedure called fecal microbiota transplantation (“FMT”).

This procedure starts with a mother’s fecal matter being screened for dangerous pathogens and when none are found, the fecal matter is orally transplanted into the infant so that the baby can develop colonies of the same microbes that the biological mother of that infant has in their gut.

During the study, a team of researchers from mainly Helsinki University got fecal samples from seventeen mothers who had delivered by C-section. When those samples were checked for potentially dangerous microbes, only seven samples were found to be safe for oral transplantation to the infants.

The infants were then given the fecal samples orally and they were monitored for any adverse reactions. None were observed. The team then compared the microbes in the guts of those infants with those of other C-section infants who hadn’t got the FMT, as well as the microbiota of infants who had been born vaginally.

Over the three months of observation, the researchers found that the gut microbiota of the FMT babies quickly resembled that of the babies born vaginally while the gut microbes of the other C-section babies who didn’t receive the FMT retained the composition observed at birth.

The researchers concluded that fecal microbiota transplantation after C-section birth was a safe and viable way to confer the benefits of a mother’s microbiota to an infant who would have otherwise missed out on those protective benefits due to not being born vaginally.

This isn’t the first time that fecal microbiota transplantation has been used. The intervention has been used with great success to restore the gut microbiota of adults, as well as to cure a number of health conditions, such as persistent clostridium difficile infections.

The use of this same technique to lower the risk of C-section babies later developing chronic health conditions is therefore a welcome application of FMT, and biomed companies like VistaGen Therapeutics Inc. (NASDAQ: VTGN) are certainly glad that C-section babies can have a chance to fix the microbiota deficiency they exhibit as a result of their method of birth.

About BioMedWire

BioMedWire (BMW) is a bio-med news and content distribution company that provides (1) access to a network of wire services via NetworkWire to reach all target markets, industries and demographics in the most effective manner possible, (2) article and editorial syndication to 5,000+ news outlets (3), enhanced press release services to ensure maximum impact, (4) social media distribution via the Investor Brand Network (IBN) to nearly 2 million followers, (5) a full array of corporate communications solutions, and (6) a total news coverage solution with BMW Prime. As a multifaceted organization with an extensive team of contributing journalists and writers, BMW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. By cutting through the overload of information in today’s market, BMW brings its clients unparalleled visibility, recognition and brand awareness. BMW is where news, content and information converge.

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Months into the coronavirus and amidst the biggest economic crisis the state has seen in a century, Washington State’s marijuana industry is going strong. Dispensaries saw a “pretty big spike” in sales in March that is still continuing into September, says David Morgan, co-owner of Lucky Leaf in downtown Spokane. With the legislature adjourned at the moment, a legislative committee that oversees the industry is considering a variety of industry reforms including increasing the amount of information on product labels, as well as keeping track of the growing number of studies supported by marijuana sales tax.

During a recent work session to study major issues faced by the state’s marijuana industry, the House Commerce and Gaming Committee gathered information on whether to provide more information about the main chemical compounds in cannabis on product labeling. Although the plant produces over 200 cannabinoids, the two most dominant and the ones found in most cannabis products are THC and CBD. THC is responsible for marijuana’s infamous “high” while cannabidiol is known to induce health benefits such as relieving pain and anxiety and combating insomnia.

The committee also looked into the state’s current limits in potency for certain products. At the moment, Washington State limits the amount of THC in a single serving of any edible product to 10 milligrams with no more than 10 such servings per package. The legislature could consider limiting the amount of THC in cannabis concentrates to 10% next year, but a bill on that subject did not make it out of committee in this year’s session.

The committee was also appraised of the studies funded by taxes imposed on cannabis sales. Washington State University (“WSU”), for instance, has a range of studies that include crime, health, agriculture, and economics, and it has been charged with studying the effects of marijuana on pregnancy and adolescence. According to Ryan McLaughlin of the Department of Integrative Psychology and Neuroscience, researchers from WSU have developed an innovative way to use rats to simulate how people consume marijuana.

A rat is placed in a small chamber that allows it to push its nose through an opening, triggering the release of cannabis extract vapor. This allows researchers to see if adolescent rats develop a preference for extracts with more THC than CBD and how the use triggers changes in the brain as they grow, McLaughlin says. Celestine Barbosa-Leiker, vice chancellor for research at WSU Health Sciences Spokane, told the committee that marijuana use among pregnant women has doubled between 2012 and 2017.

A lot of pregnant women confessed that they regularly smoke marijuana to combat morning sickness, alleviate pain, and to help them sleep. However, they were getting mixed messages from health care providers, Barbosa-Leiker says, and they were doing their own research. “They’re relying on budtenders for their scientific and medical information.”

Industry watchers say that the research-based approach to decision making in Washington State is supported by cannabis companies like The Alkaline Water Company Inc. (NASDAQ: WTER) (CSE: WTER) who prefer policymakers that are informed while they do their work.

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CNW420 spotlights the latest developments in the rapidly evolving cannabis industry through the release of two informative articles each business day. Our concise, informative content serves as a gateway for investors interested in the legalized cannabis sector and provides updates on how regulatory developments may impact financial markets. Articles are released each business day at 4:20 a.m. and 4:20 p.m. Eastern – our tribute to the time synonymous with cannabis culture. If marijuana and the burgeoning industry surrounding it are on your radar, CNW420 is for you! Check back daily to stay up-to-date on the latest milestones in the fast -changing world of cannabis.

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• Mullen Technologies begins built-out of pilot facility, accepting orders for MX-05 SUV.
• Facility slated for April 2021 completion; first MX-05 SUVs rolling off production line by Q2 2022.
• In August, Net Element, Mullen Technologies announced execution of definitive agreement to merge.

The announcement by Mullen Technologies Inc. that it has begun to build out its pilot manufacturing facility and take pre-orders for its M05 fully electric SUV bodes well for Net Element (NASDAQ: NETE). Earlier this year, Net Element, a global financial technology and value-added solutions group, and Mullen Technologies announced a merger agreement—so good news for Mullen means good news for Net Element.

“We are excited to begin the build-out of our pilot facility and pre-sales of our MX-05 SUV in October,” said Mullen Technologies chairman and CEO David Michery. “We plan on completing the build-out by April 2021 and to begin assembly of certification prototypes by July 2021. These vehicles will be used for homologation, which is expected to take 16 months and be completed by May of 2022, at which time we expect to begin delivering the first vehicles to the public.”

On Oct. 1, Mullen began work to turn its Monrovia, California-based, high-voltage battery R&D center into a state-of-the-art pilot facility where its line of fully electric SUVs will be manufactured. Plans call for the facility to be completed by April 2021, with the first MX-05 SUVs rolling off the production line to be delivered to customers by second quarter 2022.

Mullen Technologies anticipates its remodeled manufacturing facility will produce up to 1,000 MX-05 EVs per year; the facility will also manufacture all other upcoming models, including the MX-07 and MX-03. The factory will be renovated to include general assembly and battery assembly capabilities; the structure will also house R&D and serve as a warehouse.

Also on Oct. 1, Mullen will begin accepting preorders for its MX-05 model; starting base price for the innovative vehicle starts at $55,000. In addition, the company is also taking preorders for its Dragonfly K50, a limited-production super sports car being imported under Independent Commercial Importers. Information about both vehicles, as well as how to reserve the EVs, can be found on www.MullenUSA.com or at any Mullen retail location.

In August, Net Element announced the execution of a definitive agreement to merge with privately held Mullen Technologies Inc., in a stock-for-stock reverse merger in which Mullen’s stockholders will receive a majority of the outstanding stock in the post-merger company. The completion of the merger is subject to shareholder and NASDAQ approval, as well as other conditions referenced in the merger agreement.

Net Element Inc. is a global financial technology and value-added solutions group that supports electronic payments acceptance in an omni-channel environment spanning across point-of-sale, e-commerce and mobile devices. The company operates a payments-as-a-service transactional model and value-added services platform for small to medium enterprises in the United States and selected emerging markets.

For more information, visit the company’s website at www.NetElement.com.

NOTE TO INVESTORS: The latest news and updates relating to NETE are available in the company’s newsroom at http://ibn.fm/NETE

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Green Car Stocks (GCS) is a specialized communications platform with a focus on electric vehicles (EV), as well as other emerging market opportunities in the green sector. The company provides (1) access to a network of wire services via NetworkWire to reach all target markets, industries and demographics in the most effective manner possible, (2) article and editorial syndication to 5,000+ news outlets (3), enhanced press release services to ensure maximum impact, (4) social media distribution via the Investor Brand Network (IBN) to nearly 2 million followers, and (5) a full array of corporate communications solutions. As a multifaceted organization with an extensive team of contributing journalists and writers, GCS is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. By cutting through the overload of information in today’s market, GCS brings its clients unparalleled visibility, recognition and brand awareness. GCS is where news, content and information converge.

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A team of Georgia State scientists has received a two-year grant to further develop a tool to help psychiatrists better diagnose and treat mood disorders. The $875,110 grant was provided by the National Institute of Mental Health and it will fund studies that will make it easier for mental health professionals to quickly diagnose and treat mental health conditions with accuracy. The researchers are based at the Center for the Translational Research in Neuroimaging and Data Science (TReNDS).

TReNDS is a tri-institutional effort supported by Georgia State University, Georgia Institute of Technology, and Emory University that is focused on making better use of complex brain imaging data. The grant was awarded to Advanced Biomedical Informatics Group LLC, a startup led by Jeremy Bockholt. The tool the firm will develop is based on research by Vince Calhoun, Distinguished University Professor of Psychology, and a Georgia Research Alliance Eminent Scholar.

Calhoun holds appointments in Electrical and Computer Engineering at Georgia Tech and Neurology and Psychiatry at Emory University and is the founding director of TReNDS. He has collaborated with Calhoun, the leader of the study for more than 15 years. Calhoun and his team plan to use data from functional magnetic resonance imaging (“fMRI”) to allow psychiatrists to more accurately predict how patients will react to medication. Their algorithm would then use machine learning to analyze a patient’s fMRI scan and compare it to scans from thousands of other individuals.

By studying how individuals with the same brain activity reacted to medication, the tool could predict how a patient will likely respond to one medication versus another. This information will help psychiatrists decide which medication to prescribe to patients. At the moment, there are no biologically based clinical tools to diagnose mental illness, with conditions like bipolar disorder taking an average of six to ten years to properly diagnose.

“This tool can give clinicians an objective window into a patient’s brain, helping them make more tailored treatment recommendations. Regardless of the diagnosis, is the patient’s brain more similar to someone who responded better to mood stabilizers or to someone who responded better to antidepressants?” asks Bockholt. The two-year grant will allow the team to refine the algorithm by feeding it additional data, including scans from a diverse group of patients as well as scans from various types of fMRI machines.

Eric Verner, Associate Director of Innovation at TReNDS and Project Co-Investigator, George State University says that “on the previous data set, our tool was over 90% accurate in predicting medication outcomes, so that shows us that we’re on the right track. By training the model on more data, it should perform better on a wider variety of patients.”

“We’re focusing on a patient population that is difficult to diagnose and treat using current methods,” says Calhoun. “It can be hard to know what type of medication is warranted. This could help inform those decisions and get patients on the right medication sooner.”

It would be interesting to see how the functionality of this tool would improve when paired with the systems used to develop customized treatments by biomedical companies like Predictive Oncology (NASDAQ: POAI).

About BioMedWire

BioMedWire (BMW) is a bio-med news and content distribution company that provides (1) access to a network of wire services via NetworkWire to reach all target markets, industries and demographics in the most effective manner possible, (2) article and editorial syndication to 5,000+ news outlets (3), enhanced press release services to ensure maximum impact, (4) social media distribution via the Investor Brand Network (IBN) to nearly 2 million followers, (5) a full array of corporate communications solutions, and (6) a total news coverage solution with BMW Prime. As a multifaceted organization with an extensive team of contributing journalists and writers, BMW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. By cutting through the overload of information in today’s market, BMW brings its clients unparalleled visibility, recognition and brand awareness. BMW is where news, content and information converge.

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• Processa Pharmaceuticals aims to develop products where existing clinical evidence of efficacy already exists in the targeted unmet medical need condition with the drug itself or a drug with very similar pharmacology
• The Processa process focuses on the advancement of drugs that are ready for clinical development or have minimal pre-IND enabling studies to complete
• Processa’s current development pipeline features multiple clinical drug candidates, given the recent acquisitions of three additional development-focused licensing agreement since June 2020
• In total, the company’s combined scientific, development and regulatory experience has resulted in more than 30 drug approvals by the U.S. Food and Drug Administration

Processa Pharmaceuticals (NASDAQ: PCSA) aims to develop products where existing clinical evidence of efficacy already exists in unmet medical need conditions. In support of this goal, the company has assembled an unparalleled management team, board of directors and product development team featuring experts in developing drug products, from IND-enabling studies to NDA submission. In total, the team’s combined scientific, development and regulatory experience has resulted in more than 30 drug approvals by the U.S. Food and Drug Administration (“FDA”) and more than 100 meetings with the FDA while working on more than 50 drug development programs, including drug products targeted to orphan disease and unmet medical need conditions.

Headquartered in Hanover, Maryland, Processa has built a pipeline of drugs which already have some proof-of-concept clinical data supporting clinical use in their selected indications.

Development Pipeline

The Processa process focuses on the advancement of drugs that are ready for clinical development or have minimal pre-IND enabling studies to complete. More specifically, Processa:

1. Acquires drugs that already have some clinical data to support the targeted treatment – whether it be the drug itself, an analog of the drug or a drug with similar pharmacological targets;
2. Navigates through the FDA, collaborating with the reviewers to define a complete development program; and
3. Develops each drug over the course of 2-5 years, out-licensing the drug either just prior to pivotal study after Phase 2b or after the completion of the pivotal study.

Processa’s current development pipeline features multiple drug candidates, including PCS499 and PCS100. The company has also announced three additional licensing agreements since June 2020, further bolstering its clinical efforts. Each drug is briefly described below.

PCS6422

On August 27, 2020, Processa announced its entry into a contingent precedent exclusive licensing agreement with Elion Oncology Inc. to develop, manufacture and commercialize eniluracil (PCS6422) globally. PCS6422 is an oral drug to be administered with fluoropyrimidine cancer drugs (e.g., capecitabine, 5-FU) to decrease the breakdown of the cancer drug to inactive metabolites or metabolites that are known to cause unwanted side effects and to increase the anti-cancer related metabolites.

An IND for a Phase 1B study was cleared by the FDA in May 2020. The study will evaluate the safety and tolerability of several dose combinations of PCS6422 and capecitabine in advanced GI tumor patients. Processa intends to enroll the first patient in 1H2021, obtain interim results, and have a final report completed in 2H2022.

“Having worked on 5-FU and other cancer agents in the past, adding PCS6422 to our pipeline and expanding our involvement in oncology was an easy decision given the significant impact that PCS6422 may have on improving the efficacy and safety of capecitabine or other fluoropyrimidines,” CEO Dr. David Young said of the agreement.

PCS499

PCS499 as a potential treatment for necrobiosis lipoidica (“NL”) was first presented to the FDA in a pre-IND meeting in 2018. In 2019, it was the subject of an IND submission and a promising Phase 2 safety study. On March 30, 2020, Processa announced a successful meeting with the FDA regarding the design and execution of the next clinical study to evaluate the ability of PCS499 to completely close ulcers in patients with NL.

“We are pleased with the outcome of the FDA meeting and the feedback we received from the FDA. We believe that the results from our completed Phase 2 trial in NL patients, especially those with more severe ulcerated forms of NL, are encouraging and we appreciate the guidance provided by the FDA regarding our next clinical trial and the requirements to support our NDA submission,” Dr. David Young, CEO of Processa, stated in the news release.

NL is a chronic, disfiguring condition affecting the skin and tissue under the skin, typically on the lower extremities, with no currently FDA-approved treatments. More severe complications can occur, such as deep tissue infections and osteonecrosis, threatening the life of the limb. Approximately 22,500 – 55,500 people in the United States and more than 150,000 – 400,000 people worldwide are affected by the ulcerated form of NL.

YH12852

On August 20, 2020, Processa announced its entry into an agreement with Yuhan Corporation, a South Korean firm, to license YH12852, a small molecule drug in development for the treatment of functional gastrointestinal (“GI”) disorders. Under the terms of the agreement, Processa will acquire the rights to a portfolio of patents with an exclusive license to develop, manufacture and commercialize YH12852 globally, excluding South Korea.

YH12852 is a novel, potent and highly selective 5-hydroxytryptamine 4 (5-HT4) receptor agonist. Other 5-HT receptor agonists with less 5-HT4 selectivity have been shown to successfully treat GI mobility disorders such as chronic constipation, constipation-predominant irritable bowel syndrome, functional dyspepsia and gastroparesis. The less selective 5-HT4 agonists, such as cisapride, have been removed from the market because of the cardiovascular side effects associated with the drugs binding to other receptors, especially 5-HT receptors other than 5-HT4.

CEO Dr. David Young called the agreement “further evidence of Processa’s commitment to seek out novel treatments for unmet medical conditions.” Processa intends to meet with the FDA in early 2021 to further define the clinical development program. In 2021, Processa expects to initiate a Phase 2 trial in a functional GI motility-related disorder that that needs better therapeutic options, such as postoperative ileus and opioid-induced constipation.

ATT-11T

On June 1, 2020, Processa announced its entry into a licensing agreement with Aposense Ltd. for the patent rights and know-how to develop and commercialize ATT-11T, a next generation irinotecan cancer drug. In the release, CEO Dr. David Young noted that the licensing deal fit with Processa’s strategy to “continue to bring innovative products to patients with an unmet medical need condition.”

ATT-11T is a novel lipophilic anti-cancer pro-drug that is being developed for the treatment of the same solid tumors as prescribed for irinotecan. This pro-drug is a conjugate of a specific proprietary Aposense molecule connected to SN-38, the active metabolite of irinotecan. The proprietary Aposense molecule on ATT-11T allows ATT-11T to bind to cell membranes to form an inactive pro-drug depot on the cell, with SN-38 preferentially accumulating in the membrane of tumors cells and the tumor core. This unique characteristic is expected to make the therapeutic window of ATT-11T wider than irinotecan, such that the anti-tumor effect of ATT-11T will occur at a much lower dose than irinotecan with a milder adverse effect profile than irinotecan. The wider therapeutic window will likely lead to more patients responding with less side effects when on ATT-11T compared to irinotecan.

The ATT-11T licensing agreement is conditioned upon Processa’s closing of a satisfactory financing round and the listing of the company’s shares on the Nasdaq or NYSE, among other conditions.

PCS100

On September 3, 2020, Processa announced its entry into an exclusive worldwide license agreement with Akashi Therapeutics to develop and commercialization Akashi’s lead drug, HT-100. Rebranded PCS100, the candidate is an anti-fibrotic, anti-inflammatory drug demonstrated to have some clinical anti-fibrotic effect in children. Processa intends to develop PCS100 first in rare adult fibrotic related diseases such as focal segmental glomerulosclerosis (“FSGS”), idiopathic pulmonary fibrosis (“IPF”) or Scleroderma, where there are still few therapeutic options.

Management Team

David Young, Pharm.D., Ph.D. is the CEO and founder of Processa. He has over 30 years of pharmaceutical research, drug development and corporate experience. Young has served in leadership roles with a number of pharmaceutical firms throughout his career, including serving as founder and CEO of Promet Therapeutics LLC since 2015 and as Chief Scientific Officer of Questcor Pharmaceuticals from 2009 to 2014. At Questcor, he was responsible for working with the FDA on modernizing the Acthar Gel label and for obtaining FDA approval in infantile spasms. In total, Young has met with the FDA more than 100 times on more than 50 drug products and has been a key team member on more than 30 NDA/supplemental NDA approvals.

Sian Bigora, Pharm.D., is Processa’s Chief Development Officer and founder. She has over 20 years of pharmaceutical research, regulatory strategy and drug development experience, working closely with Young. Prior to joining Processa, Bigora served as Co-Founder, Director and Chief Development Officer at Promet Therapeutics LLC and as Vice President of Regulatory Affairs at Questcor Pharmaceuticals from 2009 to 2015, where she led efforts to modernize the Acthar Gel label and obtain FDA approval in infantile spasms – events which were of material importance to Questcor’s subsequent success.

Patrick Lin is Chief Business & Strategy Officer and founder of Processa. He has over 20 years of financing and investing experience in the biopharma sector. Prior to joining Processa, Lin served as Co-Founder and Chairman of Promet Therapeutics LLC. He is also founder and managing partner of Primarius Capital, a family office that manages public and private investments focused on small capitalization companies.

James Stanker has served as CFO of Processa since 2018. He has over 30 years of financial and executive leadership experience in the areas of accounting principles and audit standards, regulatory reporting, and fiscal management and strategy. He served in a financial leadership role as an audit partner at Grant Thornton from February 2000 until his retirement in August 2016, where he was responsible for managing audit quality in the Atlantic Coast market territory.

Wendy Guy is the Chief Administrative Officer and founder of Processa. She has more than two decades of experience in business operations, having worked closely with Young over the last 18 years in corporate management and operations, HR and finance. Prior to joining Processa, she was Co-Founder, Director and Chief Administrative Officer of Promet Therapeutics LLC and Senior Manager, Business Operation over the Maryland office for Questcor Pharmaceuticals.

For more information, visit the company’s website at www.ProcessaPharma.com.

NOTE TO INVESTORS: The latest news and updates relating to PCSA are available in the company’s newsroom at https://ibn.fm/PCSA

About BioMedWire

BioMedWire (BMW) is a bio-med news and content distribution company that provides (1) access to a network of wire services via NetworkWire to reach all target markets, industries and demographics in the most effective manner possible, (2) article and editorial syndication to 5,000+ news outlets (3), enhanced press release services to ensure maximum impact, (4) social media distribution via the Investor Brand Network (IBN) to nearly 2 million followers, (5) a full array of corporate communications solutions, and (6) a total news coverage solution with BMW Prime. As a multifaceted organization with an extensive team of contributing journalists and writers, BMW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. By cutting through the overload of information in today’s market, BMW brings its clients unparalleled visibility, recognition and brand awareness. BMW is where news, content and information converge.

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• Pharmaceutical services innovator Trxade Group Inc. has gained investor attention as it has emerged as a responsive healthcare market force during the ongoing COVID-19 pandemic
• As the pandemic began to unfold earlier this year, Trxade Group saw revenues jump effectively to three times their previous Q1 level, largely as a result of personal protective equipment products
• The company’s core mission has been to help small, community-centered retail pharmacies compete with large national chains through prescription drug price transparency and AI-driven protocols that help pharmacies stay abreast of what’s available
• Trxade Group’s advances in delivering services ranging from consultation to drug shipping via virtual, remote-access technology has kept it abreast of developments as the effects of the pandemic have led to social-distancing limitations

The surprise manifestation of the novel COVID-19 coronavirus and its spread as a global pandemic this year has led to a cascade of changes involving how health care is administered, perhaps most notably in the increased adoption of telehealth services.

Telehealth services have been ideally situated for meeting remote access needs amid conditions in which the potential spread of a highly contagious virus has led medical policy makers to discourage close contact between people and gatherings in large numbers, especially indoors.

Five hundred healthcare industry executives surveyed by marketing agency Boston Digital recently reported the growing use of telehealth amid the pandemic has delivered largely positive results and the majority of the respondents said some of the changes in care protocols would undoubtedly remain in effect after the pandemic ends (https://nnw.fm/QA4TV).

Integrated pharmaceutical services innovator Trxade Group (NASDAQ: MEDS) has seen growing enthusiasm about its business profile during the course of the pandemic, largely because of revenue growth that has far exceeded expectations. The Q2 report showed a more-than-triple increase year-over-year to $6.6 million, practically tripling sequentially after Q1 this year as reported in a July earnings call (https://nnw.fm/N0lsL), which sent the stock soaring 35 percent immediately after the announcement, as noted in a Q3 research summary (https://nnw.fm/X1aPJ).

The company’s artificial intelligence API is designed to streamline the transfer of information between healthcare industry businesses. Trxade’s model thereby helps smaller, independent pharmacies in particular to competitively serve patients in spite of the proliferation of large pharmaceutical chains.

But Trxade is also rolling out a first-of-its-kind bundled service that combines telehealth performance, a COVID-19 risk assessment tool and a personal protective equipment (PPE) purchasing tool. The bundled service will help businesses better deal with the medical needs of their internal corporate structures during the changing conditions as well as once the pandemic conditions have ended.

Trxade has been working to build its capital since uplisting to the Nasdaq exchange earlier this year (https://nnw.fm/idY9H) and more recently gaining inclusion on this year’s Russell’s Microcap Index (https://nnw.fm/tFNLb). The company has also brought international investor relations specialists MZ Group on board to expand the company’s strategic investor relations program across all key markets.

The growing brand in the medical technology space has attracted nearly 11,700 independent pharmacies to its network — more than 50 percent penetration among the United States’ estimated 22,000 independent pharmacies.

“Our platform lets these independents know that they’re receiving a fair price from competing suppliers on fair payment terms and often with next day delivery,” Founder, Chairman and CEO Suren Ajjarapu said during the earnings conference call. “We believe this radical price transparency, economy of scale and competition amongst suppliers leads (to) up to 10% reduction in pharmacies’ total annual drug purchase costs, with a drug-level savings of up to 90% on certain pharmaceutical products.”

For more information, visit the company’s website at www.TrxadeGroup.com.

NOTE TO INVESTORS: The latest news and updates relating to MEDS are available in the company’s newsroom at http://nnw.fm/MEDS

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NetworkNewsWire (NNW) is a financial news and content distribution company that provides (1) access to a network of wire services via NetworkWire to reach all target markets, industries and demographics in the most effective manner possible, (2) article and editorial syndication to 5,000+ news outlets (3), enhanced press release services to ensure maximum impact, (4) social media distribution via the Investor Brand Network (IBN) to nearly 2 million followers, (5) a full array of corporate communications solutions, and (6) a total news coverage solution with NNW Prime. As a multifaceted organization with an extensive team of contributing journalists and writers, NNW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. By cutting through the overload of information in today’s market, NNW brings its clients unparalleled visibility, recognition and brand awareness. NNW is where news, content and information converge.

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Over the years, Minnesota-based company Polaris (NYSE: PII) has become synonymous with Powersports, developing a variety of off-road vehicles, including the popular RZR lineup. The popular Powersports outfit is now teaming up with Zero Motorcycles, a Santa-Cruz based maker of electronic motorcycles and powertrains to electrify its lineup. On Tuesday, the two companies announced a 10-year agreement to work together to produce electrified off-road vehicles and snowmobiles.

Zero will provide the powertrain technology, hardware, and software while Polaris will develop, manufacture, and sell the vehicles. According to Zero Motorcycles CEO Sam Paschel, the companies will co-develop the technologies and vehicle platforms for this new generation of electrified Powersports with the aim of dramatically expanding the electric options currently on the market.

“Our EV expertise and millions of miles real-world, rubber-meets-the-road EV experience, coupled with Polaris’ broad product portfolio, scale, supply chain, and market leadership, makes this a game-changer for every Powersports enthusiast.”

Although Zero is renowned in the electric motorcycle space as the Tesla of motorcycles, Polaris won’t start selling Zero motorcycles at its dealerships. The partnership will initially be focused on electrifying all the products in the Polaris lineup including their market-leading side-by-side four-wheelers as well as snowmobiles. Polaris CEO Scott Wine says that the goal is to develop vehicles that are not only attractive on their own merits, but actually superior to their combustion engine counterparts.

“The vision that I have is that any customer that wants to buy an electric powertrain product in power sports can buy it from us,” he says, admitting that “it’s going to take us a while to get there.” The Powersports outfit has had some experience with electrification before: in 2011, Polaris acquired Global Electric Motorcars (“GEM”), which makes low-speed vehicles like golf-carts and shuttles. The firm has made and sold “over a billion dollars” worth of electric vehicles.

By partnering with Zero, Wine says, Polaris hopes to add new electric vehicles to its core line of off-road and power sports vehicles. “With Zero as a partner over the next decade, we feel like we can take our entire portfolio and also offer an electric powertrain alternative that, in most cases, is a better solution for our customers than the internal combustion engine that it augments.”

Zero’s engineering expertise, as well as its approach to batteries, was the main thing that attracted him to the motorcycle outfit. “Their battery density is better than any automotive company.”

It would be enlightening to hear what entities like Net Element (NASDAQ: NETE) have to say about the likelihood of the Polaris-Zero Motorcycles partnership being a game changer regarding the electrification of two and three wheelers.

About Green Car Stocks

Green Car Stocks (GCS) is a specialized communications platform with a focus on electric vehicles (EV), as well as other emerging market opportunities in the green sector. The company provides (1) access to a network of wire services via NetworkWire to reach all target markets, industries and demographics in the most effective manner possible, (2) article and editorial syndication to 5,000+ news outlets (3), enhanced press release services to ensure maximum impact, (4) social media distribution via the Investor Brand Network (IBN) to nearly 2 million followers, and (5) a full array of corporate communications solutions. As a multifaceted organization with an extensive team of contributing journalists and writers, GCS is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. By cutting through the overload of information in today’s market, GCS brings its clients unparalleled visibility, recognition and brand awareness. GCS is where news, content and information converge.

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A study that was published in the Nature Biomedical Engineering journal by Rice University bioengineers demonstrated how the researchers created blood vessel networks from 3D-printed sugar templates which they used to keep tightly packed cells alive for a 2-week period.

Ian Kinstlinger, who is the lead author of the study, said that among the biggest obstacles in developing clinically significant tissues was trying to provide enough nutrients and oxygen to all the millions of living cells in a large tissue structure.

He explained that the development of new materials and technologies that mimic vascular networks that occur naturally had significantly helped with the issue, making it easier for the researchers to provide nutrients and oxygen to plenty of cells. This increased the chances of the cells achieving therapeutic function in the long-term.

The study’s coauthor who is also an assistant professor of bioengineering at Rice University, Jordan Miller, used an open source modified laser cutter to 3D print the sugar templates in his lab.

Laser sintering was used to make these complex 3D templates. Laser sintering and extrusion create 3D shapes using 2D layers. He explained that extrusion printing could not be used in some architectures like branched networks, multivascular networks and overhanging structures. Miller started working on the laser sintering methods soon after joining Rice University in 2013.

With selective laser sintering, researchers were afforded much more control in all 3 dimensions which allowed the researchers to access the cells while simultaneously preserving the sugar material’s utility.

Sugar was used to create the blood vessel templates as it can dissolve in water without harming the surrounding cells and it’s also durable when its dry.

Kinstlinger added that the main benefit of using this method was that they could create tissue structures at a faster rate.

After creating these tissues, the research team then conducted hepatocyte experiments collaboratively with Kelly Stevens, who is a bioengineer from the University of Washington. Stevens’ research group focused on the study of these delicate hepatocyte cells, which are very hard to nourish outside a host’s body.

Stevens states that the method Kinstlinger’s group used was incredibly versatile, as it could be utilized in various material cocktails, unlike other bio-printing technologies.

Miller concluded that the team had shown that the generation of large tissue volumes and sustaining the hepatocytes in those tissues for a period of time to evaluate their function was possible. This, he said, was an exciting step forward. Do biomedical companies like DarioHealth Corp. (NASDAQ: DRIO) think that functional synthetic tissues are just a few years away from reality? Only time will tell.

About BioMedWire

BioMedWire (BMW) is a bio-med news and content distribution company that provides (1) access to a network of wire services via NetworkWire to reach all target markets, industries and demographics in the most effective manner possible, (2) article and editorial syndication to 5,000+ news outlets (3), enhanced press release services to ensure maximum impact, (4) social media distribution via the Investor Brand Network (IBN) to nearly 2 million followers, (5) a full array of corporate communications solutions, and (6) a total news coverage solution with BMW Prime. As a multifaceted organization with an extensive team of contributing journalists and writers, BMW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. By cutting through the overload of information in today’s market, BMW brings its clients unparalleled visibility, recognition and brand awareness. BMW is where news, content and information converge.

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Many countries and their economies alike have been adversely affected by the coronavirus pandemic. Countries like India plan to use this disruption to lead their economy into a rapid industrialization phase. The ace up their sleeve is the mining sector, which will be the main driver to economic recovery in a post-pandemic world.

Usually, a 1% growth in the mining sector leads to an average 1.3% increase in the industrial production growth rate while 10 indirect jobs are created from 1 direct job. According to the 12^th five-year plan of the Planning Commission of India, for every 1% rise in economic growth, the country’s mining sector generates 6 times more employment than the manufacturing sector and 13 times more job opportunities than the agricultural sector. To achieve this, serious interventions are needed in the mining sector.

The National Mineral Policy (“NMP”), which was revised last year, outlines how the Ministry of Mines encourages large scale investments with the newest technologies in prospecting and mining. By relaxing FDI rules (Foreign Direct Investment), the national mineral policy aimed for substantial investments and also developing mineral exportation strategy for the long-term would help establish the mining sector as an independent industry. Incentivizing exploration is also recommended by the NMP as a way to attract private investments.

Recently, the government allowed up to 100% FDI, with a few exceptions and also permitted commercial mining in the coal sector. This is expected to bring in more investments for the mining sector. However, it is important to realize that opening up FDI doesn’t automatically mean that huge investments are going to be flowing in. To improve the investment environment, inefficient clearance procedures and regulatory restrictions have to be addressed. Only then will the ease of doing business increase, leading to an inflow of investments.

The Ministry of Coal is helping to do just that, by developing a Single Window Clearance Mechanism, which is essentially a quicker way for online applications to be processed and approved. This move into the digital network will help make it easier to carry out business in India by allowing assignees of coal mines to secure approvals in a well-timed manner, which will allow mines to begin their operations sooner.

Despite the government’s move to open the mining sector in India under the stimulus reforms that were recently announced, the sector still has a lot unexploited potential which can be harnessed by implementing suggestions that work towards removing regulatory restrictions.

It would be interesting to see what companies like Energy Fuels Inc. (NYSE American: UUUU) (TSX: EFR) think about the suitability of the measures planned to fully exploit mining in India.

About MiningNewsWire

MiningNewsWire (MNW) is a specialized communications platform focused on developments and opportunities in the global resources sector. The company provides (1) access to a network of wire services via NetworkWire to reach all target markets, industries and demographics in the most effective manner possible, (2) article and editorial syndication to 5,000+ news outlets (3), enhanced press release services to ensure maximum impact, (4) social media distribution via the Investor Brand Network (IBN) to nearly 2 million followers, and (5) a full array of corporate communications solutions. As a multifaceted organization with an extensive team of contributing journalists and writers, MNW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. By cutting through the overload of information in today’s market, MNW brings its clients unparalleled visibility, recognition and brand awareness. MNW is where news, content and information converge.

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• Clinical-stage biotech developer CNS Pharmaceuticals is working to demonstrate the potential effectiveness of its novel drug, Berubicin, in treating aggressive and rare brain cancer glioblastoma multiforme (“GBM”)
• CNS expects to launch Phase II trials of Berubicin later this year or in Q1 of 2021, building on promising results shown in initial trials
• One patient in the Phase I trial has remained cancer-free over the course of 14 years, and 44 percent of the patients who could be evaluated experienced a clinically significant positive response to Berubicin
• CNS’s laser-focused strategy for developing a GBM therapy is also leading the company to prepare, through its sub-licensee partner WPD Pharmaceuticals, for a first-ever Phase I pediatric trial of Berubicin in Poland as well as continuing the development of the company’s second drug candidate, WP1244, which has shown tremendous promise in stopping cancer proliferation in preclinical studies comparing it to chemotherapy drug daunorubicin

CNS Pharmaceuticals (NASDAQ: CNSP) is building its technologically advanced strategy for demonstrating the potential brain tumor-fighting capabilities of its novel drug Berubicin, announcing recently an agreement with medical imaging company Image Analysis Group (“IAG”) to evaluate upcoming clinical phase II patient trial scansin real time.

IAG’s proprietary platform DYNAMIKA is an AI-driven technology developed to aid in the analysis of patient responses during pharmaceutical trial’s, and IAG has extensive experience in partnering with the biotech industry — oncology companies in particular — to provide a centralized reading of critical data, according to a news release about the partnership (https://ibn.fm/7OTsk).

CNS Pharmaceuticals is developing unique treatments for primary and metastatic cancers of the brain and central nervous system, including the company’s lead drug candidate Berubicin, which aims to treat the aggressive brain cancer glioblastoma multiforme (“GBM”) (https://ibn.fm/4r5U3).

“This drug was designed specifically to penetrate the Blood-Brain Barrier and to treat cancers in the brain, which we all know are extremely difficult given that the brain is the most privileged organ in the body,” CNS CEO John Climaco told attendees at the Oppenheimer Fall Healthcare Life Sciences & MedTech Summit as part of the company’s investment highlights presentation at the virtual conference Sept. 22 (https://ibn.fm/AzZv6).

During a 2006 Phase I clinical trial, Berubicin “appeared to demonstrate one durable, complete response against GBM,” Climaco said. The specified patient has remained cancer-free as of the last assessment on Feb. 20 of this year. Twenty-seven of the participating patients were able to be evaluated, and 44 percent of them experienced a clinically significant improvement in condition as a result of the trial.

Regarding IAG’s scientific and clinical imaging expertise in the field of GBM and the prowess of the company’s analytical API, Climaco stated, “IAG has an exemplary track record of partnering closely with companies in the biotech space to provide critical analysis of both efficacy and patient response, which we believe will be pivotal in advancing our Berubicin clinical trials.”

IAG CEO Dr. Olga Kubassova stated the platform will not only help CNS analyze Berubicin’s effectiveness and build scientific evidence of its performance but will also help the company efficiently reduce development costs, uncertainties about outcomes and timelines for the product’s advancement.

In addition to the Berubicin trials, CNS and its partner WPD Pharmaceuticals are preparing for a first-ever Phase I Berubicin trial for pediatric patients who have brain cancer. CNS is also developing a second drug candidate, WP1244, shown in preclinical studies to have a DNA-binding agent 500 times more potent than chemotherapy drug daunorubicin in stopping tumor cell expansion.

“We are laser-focused as a company at this point on a critical unmet medical need, and that is the treatment of glioblastoma, which is the most aggressive, common and incurable form of brain cancer,” Climaco told conference attendees. “If you get glioblastoma, the devastating fact is you’re going to die from that disease. After decades without progress in the treatment of this terrible disease, we believe that Berubicin could potentially be a game-changer.”

For more information, visit the company’s website at www.CNSPharma.com.

NOTE TO INVESTORS: The latest news and updates relating to CNSP are available in the company’s newsroom at https://ibn.fm/CNSP

About BioMedWire

BioMedWire (BMW) is a bio-med news and content distribution company that provides (1) access to a network of wire services via NetworkWire to reach all target markets, industries and demographics in the most effective manner possible, (2) article and editorial syndication to 5,000+ news outlets (3), enhanced press release services to ensure maximum impact, (4) social media distribution via the Investor Brand Network (IBN) to nearly 2 million followers, (5) a full array of corporate communications solutions, and (6) a total news coverage solution with BMW Prime. As a multifaceted organization with an extensive team of contributing journalists and writers, BMW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. By cutting through the overload of information in today’s market, BMW brings its clients unparalleled visibility, recognition and brand awareness. BMW is where news, content and information converge.

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A new study by the Stony Brook University indicates that fructose consumption may actually aggravate an intestinal inflammation into inflammatory bowel disease. The study, which was led by David Montrose of the Stony Brook University Renaissance School of Medicine, was published in the Cellular and Molecular Gastroenterology and Hepatology online journal.

According to the U.S. CDC, roughly three million Americans are diagnosed with Inflammatory Bowel Diseases (“IBD”) each year, which is a one million increase in the number of cases in comparison with cases in the late 90s. The number of IBD cases appears to be increasing globally as well. The consumption of a Western diet, which includes fructose, has been shown to increase the risk of diabetes and obesity. Now, it turns out Inflammatory Bowel Diseases may also be worsened by the consumption of fructose.

Montrose, who is a faculty researcher in the Cancer Center at Stony Brook University as well as an assistant professor in the Pathology department, says that the increase in the number of IBD cases corresponds with the higher fructose consumption levels in the U.S. and other nations.

The research findings indicate a dietary connection between IBD and fructose. This supports the theory that a high fructose consumption will exacerbate the ailment for people with IBD. These results, he adds, are important as they can be used to give guidance on the alternative dietary choices for individuals who have IBD.

Together with his colleagues at the Weill Cornell Medicine, Montrose ran tests using 3 IBD mouse models. They observed that feeding the mice with high fructose amounts aggravated colonic inflammation with changes in their gut bacteria metabolism, type and localization in the colon. Corresponding mechanistic work showed that the microbiota in the gut was linked to the cause of the harmful effect of the high fructose diet.

The study states in its conclusion that the consumption of dietary fructose in excess had an inflammatory effect on the colon, which could be explained by the changes in distribution, composition and metabolic function of the colonic microbiota.

Montrose reveals that the research’s next steps are to learn more about these findings, and explore further. This includes the evaluation of whether the fructose diet grows colitis-associated tumorigenesis. This is extremely important as many people with IBD have an increased risk of developing colon cancer because of the chronic inflammation of their gut for a huge part of their lives. Biotech companies like CNS Pharmaceuticals Inc. (NASDAQ: CNSP) could use these research findings to develop some life-saving interventions for people with inflammatory bowel disease in the future.

About BioMedWire

BioMedWire (BMW) is a bio-med news and content distribution company that provides (1) access to a network of wire services via NetworkWire to reach all target markets, industries and demographics in the most effective manner possible, (2) article and editorial syndication to 5,000+ news outlets (3), enhanced press release services to ensure maximum impact, (4) social media distribution via the Investor Brand Network (IBN) to nearly 2 million followers, (5) a full array of corporate communications solutions, and (6) a total news coverage solution with BMW Prime. As a multifaceted organization with an extensive team of contributing journalists and writers, BMW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. By cutting through the overload of information in today’s market, BMW brings its clients unparalleled visibility, recognition and brand awareness. BMW is where news, content and information converge.

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• VistaGen’s product portfolio consists of three novel drug candidates that, together, target multiple anxiety disorders, depression disorders and neurological disorders
• Two of the company’s drug candidates have received an FDA fast track designation, including for the treatment of social anxiety disorder, major depressive disorder and neuropathic pain.
• The global CNS therapeutics market is estimated to reach $130 billion by 2025
• The two most common mental health conditions – anxiety and depression – cost the global economy an estimated $1 trillion each year
• VistaGen is committed to developing and commercializing multiple new generation medications that go beyond the standard of care in large markets for treatment of anxiety, depression and other central nervous system (“CNS”) disorders, potentially addressing the unmet needs of millions worldwide
• The company’s efforts are advanced by a skilled management team with decades of experience in biotechnology, pharmaceuticals, CNS drug development and more

VistaGen Therapeutics (NASDAQ: VTGN) is a biopharmaceutical company committed to developing and commercializing a new generation of medications that go beyond the standard of care for anxiety, depression and other central nervous system (“CNS”) disorders.

The company is headquartered in South San Francisco, California, the “Birthplace of Biotechnology,” among the largest cluster of biotechnology companies in the world.

New Generation Medications

VistaGen currently has three innovative CNS drug candidates in its pipeline: PH94B, PH10 and AV-101. With a differentiated mechanism of action and an exceptional safety profile in all clinical studies to date, each of VistaGen’s three drug candidates offers significant commercialization potential in multiple large CNS markets.

PH94B

Fast-acting (10-15 minutes), non-systemic and non-sedating in Phase 2 clinical studies, PH94B is a first-in-class neuroactive nasal spray that, administered in microgram doses, binds to chemosensory receptors in the nasal passage that trigger neural circuits responsible for suppressing fear and anxiety caused by stressful social or performance situations.

PH94B is currently being developed as an acute treatment of anxiety in adults with Social Anxiety Disorder (“SAD”). In December 2019, PH94B became the first drug candidate to be granted Fast Track designation by the U.S. Food and Drug Administration (FDA) for development of a treatment for SAD, positioning it to potentially become the first FDA-approved fast-acting acute treatment for adults with the anxiety disorder, if planned Phase 3 studies are successful.

A successful Phase 2 program has been completed, and, after achieving consensus with the FDA in mid-2020 that the design of its Phase 3 studies of PH94B in SAD may mirror the design of the highly statistically significant (p=0.002) Phase 2 public speaking study of PH94B in SAD, the company’s preparations for pivotal Phase 3 clinical development of PH94B are underway.

To support Phase 3 development and commercialization of PH94B for anxiety disorders in large anxiety disorder markets in Asia, VistaGen recently entered into a strategic licensing and collaboration agreement with EverInsight Therapeutics, a company formed and currently funded by a large global venture capital firm, CBC Group. The company received a $5 million non-dilutive upfront license payment from EverInsight in August 2020. If Phase 3 development is successful, VistaGen is eligible to receive additional development and commercial milestone payments of up to $172 million, plus tiered royalties on sales of PH94B in Greater China, South Korea and Southeast Asia. VistaGen retains exclusive rights to develop and commercialize PH94B in all other markets.

VistaGen is also assessing potential Phase 2A clinical development opportunities to evaluate PH94B in a range of other anxiety disorders, including:

• Adjustment Disorder with Anxiety
• Generalized Anxiety Disorder
• Postpartum Anxiety
• Perioperative Anxiety
• Panic Disorder
• PTSD

PH10

PH10 is an investigational fast-acting synthetic neuroactive nasal spray with therapeutic potential in a wide range of neuropsychiatric indications involving depression and suicidal ideation. VistaGen is initially developing PH10 as a potential fast-acting, non-sedating, non-addictive new generation treatment of major depressive disorder (“MDD”).

Upon self-administration, a microgram-level dose of PH10 sprayed into the nose binds to nasal chemosensory receptors that, in turn, activate neural circuits in the brain that lead to rapid-onset antidepressant effects, without side effects, systemic exposure or safety concerns that may be caused by FDA-approved drug treatments for MDD, including oral antidepressants and intranasal esketamine.

In a published exploratory Phase 2A MDD study, PH10 demonstrated rapid-onset and sustained antidepressant effects without the serious psychological side effects and safety concerns of ketamine-based therapy.

Following successfully completed Phase 2A development of PH10 for MDD, the company is currently preparing for a Phase 2B program in MDD.

VistaGen is also assessing the potential for Phase 2A clinical development of PH10 in a range of other depression-related indications, including:

• Postpartum Depression
• Treatment-resistant Depression
• Suicidal Ideation

AV-101

Part of a class of new generation investigational medicine in neurology and neuropsychiatry known as N-methyl-D-aspartate receptor (“NMDAR”) modulators, AV-101 is an oral prodrug of 7-chloro-kynurenic acid (7-Cl-KYNA), a potent and selective NMDAR glycine site antagonist. This drug candidate has the potential to serve as an innovative treatment for MDD and multiple neurological indications where current therapies are unsatisfactory.

VistaGen is currently evaluating AV-101, in combination with FDA-approved probenecid, in a range of neuropsychiatric and neurological indications, with both MDD and Neuropathic Pain already granted Fast Track designation by the FDA. The company is assessing the combination for a potential Phase 1B study to support a potential Phase 2A program in one or more of the following indications:

• Major Depressive Disorder
• Neuropathic Pain
• Levodopa-induced dyskinesia associated with Parkinson’s disease therapy
• Epilepsy
• Suicidal Ideation

CNS Therapeutics Market Outlook

The global CNS therapeutics market is estimated to reach $130 billion by 2025. The market was valued at approximately $82.3 billion in 2017 and is anticipated to grow at a healthy CAGR of more than 5.93% from 2018 to 2025. Even before the onset of the anxiety- and depression-provoking stressors from the COVID-19 pandemic, this growth was expected to be driven by a rise in mental illnesses and increased awareness of psychiatric disorders (https://ibn.fm/TonuU) – all likely to be amplified by the diverse impacts of the pandemic.

The two most common mental health conditions – anxiety and depression – cost the global economy an estimated $1 trillion each year. The impact of these conditions is particularly devastating among the young. Industry data suggest that approximately 20% of the world’s children and teens are affected by mental health conditions, and suicide is the leading cause of death among 15- to 29-year-olds (https://ibn.fm/4yY4d).

VistaGen’s mission is to help address the unmet needs of patients suffering from CNS disorders whose current treatments are either inadequate or generate debilitating side effects and serious safety concerns, including risk of abuse and death.

“Now more than ever, the new generation anti-anxiety and antidepressant medications we are developing at VistaGen – PH94B, PH10 and AV-101 – are relevant, necessary and demand the highly-focused and passionate efforts of our team and partners, with the support of our stockholders, to advance them to patients whose lives are disrupted by anxiety and depression disorders,” VistaGen CEO and Director Shawn K. Singh said in his closing remarks at the company’s 2020 Annual Meeting of stockholders.

Management Team

Shawn K. Singh, J.D. is the Chief Executive Officer and a Director of VistaGen. He has served on the company’s board of directors since 2000. He has nearly 30 years of experience serving in numerous senior management roles across multiple industries, including private and public biotechnology, pharmaceuticals, medical devices, venture capital, contract research and development, and law. Singh has a B.A. with honors from the University of California – Berkley. He has a J.D. degree from the University of Maryland Carey School of Law. He is also a member of the State Bar of California.

1. Ralph Snodgrass, Ph.D., is the Founder, Chief Scientific Officer and Director of the company. Snodgrass has more than 20 years of experience in the biotechnology field as a senior manager. He is recognized as an expert in stem cell biology, with over 28 years of experience using stem cells as biological research tools to promote development and drug discovery. He received a Ph.D. in immunology from the University of Pennsylvania. Snodgrass has published over 50 scientific papers with more than 17 patents and a number of patent applications.

Mark A. Smith, M.D., Ph.D., is VistaGen’s Chief Medical Officer He has over 20 years of pharmaceutical industry experience, primarily with CNS drug development. Smith has been a successful leader in the discovery and development of approximately 20 investigational new drugs. He has been a part of numerous CNS-related clinical trials. Smith received a bachelor’s and Master of Science from Yale University and a Doctor of Medicine and Doctor of Philosophy in Physiology and Pharmacology from the University of California – San Diego. He completed his residency in the psychiatry department at Duke University Medical Center.

Jerrold D. Dotson, CPA, is the Vice President, Chief Financial Officer and Secretary of VistaGen. He has over 25 years of experience in senior management positions in finance and administration at both public and private companies. Dotson is a licensed CPA in California and received his B.S. degree (Cum Laude) in business administration with a concentration in accounting from Abilene Christian College.

Mark A. McPartland is the company’s Vice President of Corporate Development and Investor Relations. He has over 20 years of experience in senior management roles in corporate development and investor relations at both public and private companies. McPartland received his Bachelor’s in business administration and marketing from Coastal Carolina University.

For more information, visit the company’s website at www.VistaGen.com.

NOTE TO INVESTORS: The latest news and updates relating to VTGN are available in the company’s newsroom at https://ibn.fm/VTGN

About BioMedWire

BioMedWire (BMW) is a bio-med news and content distribution company that provides (1) access to a network of wire services via NetworkWire to reach all target markets, industries and demographics in the most effective manner possible, (2) article and editorial syndication to 5,000+ news outlets (3), enhanced press release services to ensure maximum impact, (4) social media distribution via the Investor Brand Network (IBN) to nearly 2 million followers, (5) a full array of corporate communications solutions, and (6) a total news coverage solution with BMW Prime. As a multifaceted organization with an extensive team of contributing journalists and writers, BMW is uniquely positioned to best serve private and public companies that desire to reach a wide audience of investors, consumers, journalists and the general public. By cutting through the overload of information in today’s market, BMW brings its clients unparalleled visibility, recognition and brand awareness. BMW is where news, content and information converge.

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A projection of sales shows the recreational cannabis industry in New Jersey reaching between $850 and $950 million annually by 2024. The state, which has a population of almost 9 million people, will be holding a vote for residents to legalize a recreational marijuana market come November. For many, this is a risk they are willing to invest in, with billions of dollars’ worth of business opportunities riding on the outcome of the vote.

If New Jersey residents approve the marijuana market, many leaders expect a similar chain of events to occur inland and along the Eastern Seaboard, which will create an adult-use cannabis region that will be among the largest globally.

The total population of the states that have been in talks about adult-use legalization which include Pennsylvania, New York, Rhode Island and Connecticut, is 37 million, which is more than four times the number of people who reside in New Jersey.

With a recreational cannabis industry already established in Massachusetts and another smaller market set to launch on October 9 in Maine, the president of the CannaBusiness Association, New Jersey, Scott Rudder, predicts that New Jersey is the last hurdle for Pennsylvania, New York and the surrounding states.

A cannabis attorney, Bridget Hill-Zayat, agrees with Rudder, stating that the legalization of a recreational cannabis market in New Jersey will motivate the surrounding states.

Despite the New Jersey proposal lacking some details like the number of business licenses that will be made available, regulations and laws will be added on by cannabis regulators and state legislators after voters pass the initiative.

According to a DKC Analytics poll that was conducted in July, 68% favor the legalization initiative with 26% against it and another 6% polling as unsure. An earlier poll that was carried out in April by the Monmouth University showed that 61% of the respondents were in favor of the legalization.

At the moment, the state has only 12 medical cannabis dispensaries with a few more expected to open in the months to come. Many believe that the medical marijuana dispensaries currently operating will be the first to operate in the adult-use market, as a way to accelerate but also ease the market’s launch by late 2021.

Rudder predicts a level of urgency from legislators to give the authority and for regulators to establish regulations due to the pressure the sector will be under to create economic opportunities and generate tax revenue. This is mainly because of the effect the coronavirus pandemic has had on the state’s economy. These anticipated economic benefits confirm what the marijuana industry, including companies like The Alkaline Water Company Inc. (CSE: WTER) (NASDAQ: WTER), has always believed about the immense benefits of having a regulated cannabis market.

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A new study that centered on global coronavirus transmission data discovered that young people and children are about 40% less likely to be infected with COVID-19 as compared to adults when exposed to an individual who has the virus.

The study, which was co-led by researchers from University College London and published in JAMA Pediatrics, added more than 13,900 studies to its May pre-print in order to update their meta-analysis and systematic review. The additional studies were used to understand how susceptible children were to the coronavirus and whether they transmitted the infection to others.

Professor Russell Viner, who is the lead author of the study stated that they their findings showed that children between 12-14 years appeared significantly less likely to contract the coronavirus from other infected individuals. This comes after the study had assessed two times as many coronavirus population screening and contact tracing studies, which provided them with strong data and conclusions.

However, the data on teenagers was less clear, which led the researchers to assume that teens were just as susceptible to the virus as adults. The research findings discovered that susceptibility was an important element in the chain of infection. The findings also supported the notion that children were likely to play a much smaller role in virus transmission and multiplication of cases in the pandemic, although some uncertainty still remains.

The professor added that the new data discovered would provide additional proof that would be important to governments globally, assisting them in their decision-making to keep learning institutions open amid the pandemic.

The researchers screened a total of 13,962 studies which had been published on PubMed and MedRxiv. These studies helped them determine the 32 studies from 21 nations globally that had useful data. In their entirety, the studies included 268,945 adults and 41,640 young people and children. Young people were defined as individuals under the age of 20 in these studies.

The analysis highlights that young people and children, who are under or between the ages of 12 to 14 had a 44% less chance of contracting SARS-CoV-2 from an infected individual in comparison with adult aged above 20.

While the study gives no information concerning the infectiousness of children, it concludes that children would play a very small role in SARS-CoV-2 transmission at a population level seeing as very few children would be infected by the virus for starters. This conclusion is likely to come as good news to biomedical entities like Predictive Oncology (NASDAQ: POAI) since there is one less vulnerable section for society to worry about during this pandemic.

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