(IART) Features New MAYFIELD(R) 2 System at AANS

PLAINSBORO, N.J., May 1, 2015  — Integra LifeSciences Holdings Corporation (Nasdaq:IART) today announced the introduction of the new MAYFIELD^® 2 system for rigid cranial fixation. The MAYFIELD 2 system will be featured at the Integra LifeSciences exhibition booth at the American Association of Neurological Surgeons Annual Meeting, May 2-6, 2015, in Washington, D.C.

“MAYFIELD is among the most trusted brands in cranial stabilization, and Integra is very pleased to offer continued innovations to the MAYFIELD cranial stabilization product line started by Dr. Frank H. Mayfield, over 40 years ago,” said Robert T. Davis, Jr., President of Integra Specialty Surgical Solutions. “Integra’s new MAYFIELD 2 system has enhanced features that make the clamp easier to use and allow the surgeon to more precisely position the patient’s head to prepare for delicate neurosurgical procedures.”

The MAYFIELD 2 system consists of a new Skull Clamp, along with a new Base Unit. The MAYFIELD 2 Skull Clamp is composed of a new stronger and lighter weight material. It includes an increased amount of off-set ratcheting teeth for more precise closure, an I-beam for smoother closure, and a new dual button release for easier removal. The MAYFIELD 2 Base Unit features a powder-coated finish, which allows automatic washing, and a swivel adaptor that does not require any additional tools for adjustment.

MAYFIELD cranial stabilization systems are used worldwide in over 200,000 neurosurgical procedures annually. These procedures include craniotomy for tumor removal, treatment of head trauma injuries, pediatric disorders such as hydrocephalus, biopsies, cancer removal, cerebrovascular disorders such as aneurysms, posterior cervical spine conditions and neurodegenerative disorders such as Parkinson’s disease or epilepsy. Integra is a leading provider of implants, devices, instruments and systems used in neurosurgery, neuromonitoring, neuro-trauma and related neurocritical care.

Integra LifeSciences, a world leader in medical technology, is dedicated to limiting uncertainty for caregivers, so they can concentrate on providing the best patient care. Integra offers innovative solutions, including leading regenerative technologies, in specialty surgical solutions, orthopedics and tissue technologies, and spine hardware and orthobiologics. For more information, please visit www.integralife.com.

This news release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995.  Forward-looking statements include, but are not limited to, statements concerning the products and services provided by Integra.  Such forward looking statements involve risks and uncertainties that could cause actual results to differ materially from predicted or expected results.  Among other things, the willingness of surgical professionals to use Integra products may affect the prospects for their use in surgical procedures.  In addition, the economic, competitive, governmental, technological and other factors, identified under the heading “Risk Factors” included in Item IA of Integra’s Annual Report on Form 10-K for the year ended December 31, 2014 and information contained in subsequent filings with the Securities and Exchange Commission could affect actual results.

MAYFIELD is a registered trademark of SM USA Inc. and is used by Integra under license.

CONTACT: Integra LifeSciences:
         Media
         Gianna Sabella
         609-936-2389
         gianna.sabella@integralife.com

         Investors
         Angela Steinway
         609-936-2268
         angela.steinway@integralife.com